糖心原创

Department of Tissue Engineering and Regenerative Medicine

PUBLICATIONS

Explore our past publications highlighting advancements in tissue engineering and regenerative medicine, showcasing innovative approaches, biomaterial development and translational research that contribute to the future of healthcare.

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Total Articles Published for Year 2026

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Articles Published in TOP 10% Journal (Year 2026)

READ OUR TOP 10% JOURNAL

REVIEW

Jiao Tian, Yun Zhi Chin, Min Hwei Ng, Kok Lun Pang, Jia Xian Law

Published: 8th January 2026

International Journal of Nanomedicine (q1, if 6.5)

Abstract: Breast cancer is the most prevalent malignancy among women, with triple-negative breast cancer (TNBC) being the most aggressive subtype. The lack of standard targeted therapies necessitates reliance on chemotherapy, which often suffers from poor targeting and significant off-target toxicity. This systematic review evaluates the therapeutic potential of drug delivery systems based on extracellular vesicles (EVs) for TNBC using 17 studies from 2020 to 2024 published in Scopus, PubMed, and Web of Science. The review discusses the diverse therapeutic cargos delivered by EVs, including chemotherapeutic agents and nucleic acids, while emphasizing the need for standardized protocols to facilitate EV isolation and characterization. Key findings provide both in vitro and in vivo evidence of the efficacy of EV-based therapies against TNBC cell lines and animal models, alongside insights into engineering strategies that enhance targeting specificity. Despite the promising findings, challenges remain in clinical translation, such as technical limitations and inconsistent reporting. The results underscore the potential of EVs to revolutionize TNBC treatment strategies, paving the way for more effective therapeutic options…

Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by disrupted epidermal barrier function, immune dysregulation, and persistent inflammation. Affecting both children and adults, AD significantly impairs quality of life due to its visible symptoms and associated psychosocial and economic burdens. Traditional treatments such as application of topical corticosteroids, calcineurin inhibitors, moisturizers and antibiotics, while managing symptoms, often fall short of providing long-term solutions and can lead to adverse effects over time. This review explores innovative approaches to AD management, focusing on the therapeutic potential of the secretome. The secretome, a collection of bioactive molecules secreted by cells, has shown promise in promoting tissue regeneration and modulating immune responses. This study investigates how secretome therapy can restore the integrity of keratinocytes, the primary cells responsible for maintaining the skin barrier, which is severely compromised in AD…

REVIEW

Ponnhmalar Subramaniam, Mohamad Nasir Shafiee, Nur Izzah Md Fadilah, Mh Busra Fauzi, Manira Maarof

Published: 5th February 2026

International Journal of Nanomedicine (Q1, IF 6.5)

REVIEW

Siti Balqis Adnan, Fang Lim, Haslina Ahmad, Manira Maarof, Mh Busra Fauzi, Nur Izzah Md Fadilah

Published: 27th March 2026

International Journal of Nanomedicine (Q1, IF 6.5)

Abstract: The advancement of nanomedicine has significantly reshaped drug delivery strategies by overcoming key limitations of conventional pharmacotherapy, such as off-target toxicity, poor bioavailability, and adverse drug reactions (ADRs). Among emerging delivery platforms, peptide-based nanocarriers offer high biocompatibility, molecular specificity, and structural versatility for precision targeting. This review presents a comprehensive synthesis of current progress in the design, fabrication, and therapeutic application of peptide-functionalized nanocarriers for targeted drug delivery. Literature published between 2016 and 2025 was examined, with particular focus on strategies for peptide incorporation, including physical encapsulation, chemical conjugation, and self-assembly. Diverse nanocarrier platforms are discussed, including liposomes, solid lipid nanoparticles (SLNs), dendrimers, polymeric micelles, mesoporous silica nanoparticles (MSNs), and hybrid systems. Recent innovations in biodegradable polymers, co-delivery platforms, multifunctional assemblies, and stimuli-responsive formulations are highlighted. Advances in peptide design, particularly the use of cyclic and stapled peptides, have improved structural stability, target affinity, and bioavailability…

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