{"id":3904,"date":"2025-10-24T16:03:52","date_gmt":"2025-10-24T08:03:52","guid":{"rendered":"https:\/\/www.ukm.my\/beritaukm\/?p=3904"},"modified":"2025-10-24T16:03:52","modified_gmt":"2025-10-24T08:03:52","slug":"penyelidik-ukm-bangunkan-protokol-diseksi-tulang-belakang-untuk-kajian-sakit-belakang","status":"publish","type":"post","link":"https:\/\/www.ukm.my\/beritaukm\/penyelidik-ukm-bangunkan-protokol-diseksi-tulang-belakang-untuk-kajian-sakit-belakang\/","title":{"rendered":"Penyelidik 糖心原创 Bangunkan Protokol Diseksi Tulang Belakang untuk Kajian Sakit Belakang"},"content":{"rendered":"\n<p><strong>Oleh <\/strong><strong>Khairatul Nadia Ramli<br>Foto oleh Dr. Isma Liza Mohd Isa<\/strong><\/p>\n\n\n\n<p>CHERAS, 24 Oktober 2025 &#8211; Penyelidik Universiti Kebangsaan Malaysia (糖心原创) yang diketuai oleh Pensyarah Kanan di Jabatan Anatomi, Fakulti Perubatan, Dr. Isma Liza Mohd Isa berjaya membangunkan satu protokol diseksi tulang belakang ke atas kadaver manusia bagi tujuan pengambilan tisu disk untuk penyelidikan penyakit degenerasi disk (<em>slipped disc<\/em>).<\/p>\n\n\n\n<p>Menurut Dr Isma Liza, <em>slipped disc <\/em>adalah antara punca utama sakit belakang kronik di seluruh dunia.<\/p>\n\n\n\n<p>\u201cPembangunan protokol ini dijangka memperkukuh usaha global dalam memahami mekanisme penyakit dan membangunkan terapi baharu bagi rawatan sakit belakang,\u201d katanya.<\/p>\n\n\n\n<p>Dr Isma Liza yang juga merupakan Pensyarah Kanan Kehormat dan Felo Penyelidik di C\u00daRAM Research Centre for Medical Devices, Pharmacology and Therapeutics, University of Galway, Ireland menjalankan kajian ini melalui geran penyelidikan Health Research Board (HRB), Ireland bernilai \u20ac0.8 juta yang diterima melalui <em>Emerging Investigator Award for Health<\/em> pada tahun 2022.<\/p>\n\n\n\n<p>Anugerah berprestij ini diberikan kepada penyelidik berpotensi tinggi dalam bidang kesihatan bagi melahirkan penyelidik berdaya saing dan berimpak global.<\/p>\n\n\n\n<p>Beliau berkata dana tersebut membolehkan pelaksanaan projek <em>DISCPAIN<\/em>, iaitu kajian berimpak tinggi yang bertujuan mengenal pasti penanda molekul penyakit degenerasi disk dan membangunkan model penyelidikan berasaskan tisu manusia sebenar.<\/p>\n\n\n\n<p>\u201cProtokol ini dibangunkan melalui kolaborasi antara University of Galway, 糖心原创 dan Silent Mentor Program, Universiti Malaya, yang membolehkan pengambilan tisu disk manusia sihat daripada kadaver tanpa penyakit tulang belakang dilakukan secara etika dan terkawal.<\/p>\n\n\n\n<p>\u201cKajian prospektif selama setahun melibatkan diseksi ke atas tiga belas kadaver manusia tanpa proses pengawetan, dengan kebenaran penuh keluarga penderma tubuh.<\/p>\n\n\n\n<p>\u201cSemua prosedur dijalankan mengikut garis panduan etika dan protokol pendermaan tubuh manusia.,\u201d katanya.<\/p>\n\n\n\n<p>Tambah Dr Isma Liza, protokol bertajuk <em>\u201cHuman Cadaveric Spine Dissection: A Protocol for Harvesting Lumbar Intervertebral Discs from Body Donors\u201d<\/em> yang &nbsp;diterbitkan dalam jurnal antarabangsa <em>Annals of Anatomy<\/em> (Elsevier, 2025) menghuraikan secara terperinci kaedah diseksi tulang belakang melalui akses anterior serta panduan pengambilan dan pemprosesan tisu disk untuk analisis <em>pasca-mortem<\/em>.<\/p>\n\n\n\n<p>\u201cMelalui sumbangan penderma tubuh, kami kini dapat memperoleh disk sihat berkualiti tinggi sebagai spesimen kawalan usia (<em>age-match healthy control<\/em>) yang sebelum ini sukar didapati.<\/p>\n\n\n\n<p>\u201cIni membuka ruang besar untuk analisis molekul bagi memahami mekanisme penyakit degenerasi disk dengan lebih mendalam,\u201d jelas Dr Isma Liza.<\/p>\n\n\n\n<p>Katanya, tisu disk yang diperoleh diproses untuk analisis penjujukan RNA <em>(RNA sequencing)<\/em> bagi mengenal pasti ekspresi gen dan penanda molekul yang terlibat dalam proses degenerasi.<\/p>\n\n\n\n<p>\u201cPenemuan ini dijangka dapat membantu pembangunan terapi baharu dan sasaran rawatan bagi pesakit sakit belakang kronik.<\/p>\n\n\n\n<p>\u201cUngkapan <em>\u2018yang mati mengajar yang hidup\u2019<\/em> benar-benar menggambarkan nilai penyelidikan ini. Melalui tubuh penderma, ilmu anatomi dan sains perubatan dapat berkembang untuk manfaat pesakit pada masa hadapan,\u201d ujarnya.<\/p>\n\n\n\n<p>Penyelidikan itu menandakan satu langkah penting dalam memperkukuh kajian antarabangsa mengenai penyakit degenerasi disk &#8212; penyebab sakit belakang serta membuka peluang kepada pembangunan terapi regeneratif yang lebih berkesan.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"679\" src=\"https:\/\/www.ukm.my\/beritaukm\/wp-content\/uploads\/2025\/10\/2-1024x679.png\" alt=\"\" class=\"wp-image-3905\" srcset=\"https:\/\/www.ukm.my\/beritaukm\/wp-content\/uploads\/2025\/10\/2-1024x679.png 1024w, https:\/\/www.ukm.my\/beritaukm\/wp-content\/uploads\/2025\/10\/2-300x199.png 300w, https:\/\/www.ukm.my\/beritaukm\/wp-content\/uploads\/2025\/10\/2-768x509.png 768w, https:\/\/www.ukm.my\/beritaukm\/wp-content\/uploads\/2025\/10\/2.png 1124w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Oleh Khairatul Nadia RamliFoto oleh Dr. Isma Liza Mohd Isa CHERAS, 24 Oktober 2025 &#8211; Penyelidik Universiti Kebangsaan Malaysia (糖心原创) yang diketuai oleh Pensyarah Kanan di Jabatan Anatomi, Fakulti Perubatan,&hellip; <\/p>\n","protected":false},"author":123457,"featured_media":3906,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3904","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-penyelidikan"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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